Air date: Wednesday, December 07, 2011, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: O-GlcNAcylation, the cycling of a N-acetylglucosamine monosaccharide on Ser(Thr) residues of nuclear and cytoplasmic proteins, serves as a nutrient/stress sensor to regulate signaling, transcription and cellular metabolism. Recent phospho- and glycomic approaches have shown that an increase in global O-GlcNAcylation affects phospho-site occupancy at nearly every actively cycling site. A chemico-enzymatic photochemical enrichment method, combined with ETD-mass spectrometry allows detection of O-GlcNAc site occupancy at a level of sensitivity comparable to that possible for phosphorylation. These analyses show that crosstalk between site-specific phosphorylation and O-GlcNAcylation is extensive. Many kinases are both modified and regulated by O-GlcNAcylation. The major sensor of cellular energy state, AMPK is O-GlcNAcylated. AMPK and O-GlcNAc transferase share many substrates and the two systems directly interact. Major signaling cascades (eg. CDK1, aurora kinase, polo kinase) that regulate cell division are strikingly affected by a small change in O-GlcNAcylation. O-GlcNAc is part of the histone code, but many of the O-GlcNAc residues are at sites interacting with DNA in the nucleosome, not in the histone tails. Multiple core ribosome proteins are modified by O-GlcNAc, which plays a role in ribosome biogenesis and …

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Canadian Association of Wound Care foot care video for people with diabetes. How to take care of your feet.
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A summary of the Junior Health Brokers 2009 summer training conducted by the Erie Niagara Health Education Center, Inc. The training focused on the various stages of diabetes, preventing diabetes, and diabetes management,
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December 16th, 2010

Believing that people with diabetes should be the best prepared and motivated to take charge of their health, Taking Control of Your Diabetes (TCOYD) offers a unique and very personal way to understand diabetes and to educate patients to become the most active members of their health care teams. Through conferences and health fairs held in cities across the nation, TCOYD annually brings thousands of people with diabetes, those at risk and their loved ones into contact with national and local medical professionals and others with expertise related to living with the disease for a day of highly informative and motivational programs. TCOYD participants can hear lectures, participate in screenings, and speak one-on-one with diabetes specialists including physicians, exercise specialists, dietitians, diabetes educators, podiatrists, pharmacists and ophthalmologists. Throughout the sessions, participants receive unbiased information on the latest findings of clinical research, the emergence of new equipment and medications, proper diet and exercise, legal and insurance issues, and the resources that are available to people with diabetes and their families. At the midday break, a seated banquet luncheon features an entertaining and inspirational speaker, who shares something from his or her own experience of living with diabetes. A health fair with 50+ informational exhibits from national and local diabetes-related companies and organizations is open throughout the day.

sites.google.com Diabetes and neuropathy: a simple explanation by Jan M. Keppel Hesselink, MD, PhD, president Foundation IOCOB and founder of the clinic for treatment of neuropathy in Soest, the Netherlands and professor of pharmacology. Diabetic neuropathy is long-term damage to the nerve fibres. The nerve damage affects each foot equally and eventually spreads up the legs and hands. Some people with diabetes will not develop nerve damage, while others may develop this condition early. Symptoms generally begin 10 to 20 years after the diabetes diagnosis. Approximately half of all people with diabetes will eventually develop neuropathy. A good control of blood glucose has a tremendous impact on preventing this disease. In 1993 the Diabetes Control and Complications Trial showed the importance of bllod sugar control, keeping blood sugar levels close to the normal range and thus reducing the risk of developing neuropathy by 60 percent. A good control of blood glucose has a tremendous impact on preventing this disease. In 1993 the Diabetes Control and Complications Trial showed the importance of blood sugar control, keeping blood sugar levels close to the normal range and thus reducing the risk of developing neuropathy by 60 percent. This means frequent testing of blood sugar, and the so called HbA1C levels in the blood, basing insulin intake on the basis of diet and exercise, following a simpel and straighforward diet and exercise plan, and staying in close contact with …
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Diabetic Foot Care – Podiatrist in Dayton, OH According to the American Diabetes Association, about 15.7 million people (5.9 percent of the United States population) have diabetes. Nervous system damage (also called neuropathy) affects about 60 to 70 percent of people with diabetes and is a major complication that may cause diabetics to lose feeling in their feet or hands. Foot problems are a big risk in diabetics. Diabetics must constantly monitor their feet or face severe consequences, including amputation. With a diabetic foot, a wound as small as a blister from wearing a shoe that’s too tight can lead to a lot of damage. Diabetes decreases blood flow, so injuries are slow to heal. When a wound is not healing, is at risk for infection and infections spread quickly in diabetics. When a diabetic foot becomes numb, it may be at risk for deformity. One way this happens is through ulcers. Small, unattended cuts become open sores, which may then become infected. Another way is the bone condition CharcotFoot. This is one of the most serious foot problems diabetics face. It warps the shape of the foot when bones fracture and disintegrate, and yet, because of numbness there is no pain, and the individual continues to walk on the foot. Our practice can treat diabetic foot ulcers and early phases of Charcot (pronounced “sharko”) fractures using a total contact cast and prevent more serious damage or deformity. This treatment allows the ulcer to heal by distributing weight and …

According to the American Diabetes Association, about 15.7 million people (5.9 percent of the United States population) have diabetes. Nervous system damage (also called neuropathy) affects about 60 to 70 percent of people with diabetes and is a major complication that may cause diabetics to lose feeling in their feet or hands. Foot problems are a big risk in diabetics. Diabetics must constantly monitor their feet or face severe consequences, including amputation. With a diabetic foot, a wound as small as a blister from wearing a shoe that`s too tight can cause a lot of damage. Diabetes decreases blood flow, so injuries are slow to heal. When your wound is not healing, it`s at risk for infection. As a diabetic, your infections spread quickly. If you have diabetes, you should inspect your feet every day. Look for puncture wounds, bruises, pressure areas, redness, warmth, blisters, ulcers, scratches, cuts and nail problems. Get someone to help you, or use a mirror. Here`s some basic advice for taking care of your feet: Always keep your feet warm. Don`t get your feet wet in snow or rain. Don`t put your feet on radiators or in front of the fireplace. Don`t smoke or sit cross-legged. Both decrease blood supply to your feet. Don`t soak your feet. Don`t use antiseptic solutions, drugstore medications, heating pads or sharp instruments on your feet. Trim your toenails straight across. Avoid cutting the corners. Use a nail file or emery board. If you find an ingrown toenail …
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For people suffering from diabetes, careful meal planning and diet control can literally be the difference between life and death. Think of MealEasy’s Diabetic Meal Plan as your personalized lifeline. .900+ delicious and safe diabetic meals .Quick and easy customizable meal plans .Automatically generated shopping lists Since our chef-designed meals are easy to prepare and great tasting, maintaining a healthy diet has never been simpler. If you have 45 minutes to prepare a meal, you can control your diabetes. Are you tired of walking through grocery aisles in confusion, or experimenting with expensive drugs? Take back control with MealEasy’s safe and delicious Diabetic Meal Plan. Diet monitoring is the best way to treat and prevent diabetes (period). We know meal planning can be complicated, but our Diabetic Meal Plan makes treatment simple — not to mention tasty! To get started, visit: www.mealeasy.com Blog blog.mealeasy.com Facebook www.facebook.com
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diabeticdietzone.com DiabeticDietZone.com is the best place for Diabetic Articles, Diabetes Information, Diabetic Types, Diabetes Forums. Come visit us today for 2 free Diabetes Ebooks!
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Video clip topics: nutritional Strategy, biomarkers, wellness factors, power, six-stage model for medical doctors, designed by DeWayne McCulley; foundation for diabetes cookbook

Josh Rosenfeld, MS, CSCS Owner: FT Sudbury, FT Wayland , FT Natick. Josh talks about talks about the Fitness Together program as a sane solution to our nation’s exploding costs of obesity and diabetes care. Josh has over a 15 years of experience in the field of health and fitness, and has worked in various settings including rehabilitation, strength and conditioning, and general fitness training. His educational background includes a BS in Biology from Hobart College and Masters degrees in Exercise Physiology and Sport Psychology from Ithaca College. He is a Certified Strength and Conditioning Specialist through the National Strength and Conditioning Association (NSCA) and a Certified Health/Fitness Instructor through the American College of Sports Medicine (ACSM). Josh has also worked as a presenter and examiner for the ACSM certification preparatory course. Josh opened the doors to Fitness Together Sudbury in January of 2002, and also currently owns Fitness Together Wayland and Natick. FT Natick fitnesstogether.com FT Sudbury fitnesstogether.com FT Wayland fitnesstogether.com For more studios in Eastern New England www.FTGetsResults.com

As the leading cause of non-traumatic, lower-limb amputations, diabetes is reaching epidemic proportions, now more than ever. It can have a devastating impact on the body, affecting numerous parts of the body including the eyes, mouth and feet. In fact, the feet, often overlooked at routine checkups, can reveal the first signs and symptoms of the disease. All too often, patients forget to take off their shoes and socks and ask their health care providers to inspect their feet. Close to 24 million people in the United States have diabetes and nearly 6 million people have it and do not even know it. Thats why its important to elect to save your feet whether you have the disease or not. Know the signs and symptoms of diabetes and have your feet checked every time you visit the doctor. 1. Why should I ask my doctor to take off my shoes and socks? The feet, said to be mirrors of our general health, can reveal diabetes warning signs such numbness, redness, swelling or non-healing wounds. Taking off your shoes and socks at every doctors visit is critical to the prevention and treatment of systemic diseases such as diabetes. 2. Who is at risk for diabetes? While many Americans are predisposed to have the disease based on family history, Hispanics, African Americans, American Indians, Asian Americans and Pacific Islanders are more at risk. People with type 2 diabetes can do a great deal to lower their chances of getting the disease such as exercising regularly, reducing fat and …